熱帶生物源農藥創制及應用-孫然鋒

團隊名稱：365英国上市官网在线熱帶生物源農藥創制及應用團隊

所屬協同創新中心：南繁與熱帶高效農業協同創新中心

團隊負責人：

孫然鋒，365英国上市官网在线副院長，熱帶農林生物災害綠色防控教育部重點實驗室副主任，中國植物保護學會化感專業委員會委員，海南省植物保護學會理事，365英国上市官网在线C類高層次人才，入選“南海名家”青年項目。近5年主持國家自然科學基金2項，海南省煙草局科技計劃項目1項等。在綠色農藥創制方面具有突出專長和豐富經驗，并取得顯著成績，發現高活性殺蟲殺菌化合物10餘個，其中高效低毒化合物叔肟蟲脲已轉讓江蘇藍豐生物化學有限公司進行登記。針對苯甲酰脲類昆蟲生長調節劑開展系統構效關系研究，提出苯甲酰脲與害蟲的作用靶點為雙作用位點的觀點，得到國内外同行的認可，并受邀在農藥學頂級期刊《Journal of Agricultural and Food Chemistry》（2015, 63, 31, 6847-6865）撰寫了苯甲酰脲類幾丁質合成抑制劑發展40年的綜述文章。先後在《Journal of Agricultural and Food Chemistry》《Industrial Crops and Products》《Pest Management Science》等國際知名期刊發表SCI論文30餘篇，申請中國發明專利9項，已授權4項。目前發現廣譜熱帶植物源殺菌劑1個，其殺菌譜和殺菌活性活性優于商品化植物源殺菌劑（蛇床子素、丁香酚、香芹酚），已獲授權中國專利，有望開發為新型植物源殺菌劑；發現熱帶植物源殺線蟲植物4種，基于“來自自然再回歸自然”的生态防控理念，開發殺線蟲植物有機肥1種，田間藥效試驗證明該有機肥可明顯降低土壤中根結線蟲對黃瓜和雪茄煙的侵染，并保持土壤中自由線蟲的生态多樣性。

團隊研究方向：

1．熱帶植物源農藥先導發現及結構優化；

2．綠色化學農藥設計及合成；

3．根結線蟲與植物互作信息物質的結構鑒定及生态學功能研究；

4．根結線蟲綠色防控技術研究。

團隊成員：

1. 李棟，副教授

2. 胡展，講師

3. 謝佳，講師

4. 王帥，講師

團隊代表性成果：

代表性論文：

1. Zhang, Xi; Hu, Zhan; Wang, Shuai; Yin, Fengman; Wei, Yuyang; Xie, Jia; Sun, Ranfeng*, Discovery of 2-Naphthol from the Leaves of Actephila merrilliana as a Natural Nematicide Candidate. Journal of Agricultural and Food Chemistry 2023, 71 (36), 13209-13219.

2. Li, Dong; Zhou, Chunran; Wang, Shuai; Hu, Zhan; Xie, Jia; Pan, Canping*; Sun, Ranfeng*, Imidacloprid-induced stress affects the growth of pepper plants by disrupting rhizosphere-plant microbial and metabolite composition. Science of The Total Environment 2023, 898, 165395.

3. He, Jianguo; Dou, Menglan; Xie, Jia; Hou, Shuai; Liu, Qifeng; Hu, Zhan; Zhang, Beijing; Zheng, Shuai; Yin, Fengman; Zhang, Meng; Xie, Changping; Lu, Dadong; Ding, Xiaofan; Zhu, Chaohua; Sun, Ranfeng*, Discovery of zeylenone from Uvaria grandiflora as a potential botanical fungicide. Pest Management Science 2021, 77 (12), 5407-5417.

4. Yin, Fengman; Liu, Qifeng; Zhang, Beijing; Zhang, Xi; He, Jianguo; Xie, Jia; Hu, Zhan; Sun, Ranfeng*, Microemulsion preparation of Waltheria indica extracts and preliminary antifungal mechanism exploration. Industrial Crops and Products 2021, 172, 114000.

5. Zhang, Meng; Dou, Menglan; Xia, Yingying; Hu, Zhan; Zhang, Beijing; Bai, Yongxia; Xie, Jia; Liu, Qifeng; Xie, Changping; Lu, Dadong; Hou, Shuai; He, Jianguo; Tao, Jun; Sun, Ranfeng*, Photostable 1-Trifluoromethyl Cinnamyl Alcohol Derivatives Designed as Potential Fungicides and Bactericides. Journal of Agricultural and Food Chemistry 2021, 69 (19), 5435-5445.

6. Yu, Xiuqiang^†; Zhu, Xinyue^†; Zhou, Yang; Li, Qinglin; Hu, Zhan; Sun, Ranfeng*, et al. Discovery of N-Aryl-pyridine-4-ones as Novel Potential Agrochemical Fungicides and Bactericides. Journal of Agricultural and Food Chemistry, 2019, 67(50): 13904-13913.

7. Liang, Cai; Yang, Li; Shao, Yu; Zhu, Xinyue; Sun, Ranfeng*, et al. Broad-spectrum antifungal activity of dichloromethane extract of Waltheria indica stems and isolated compounds. Industrial Crops and Products. 2019, 142: 111855.

8. Zhao, Qiqi; Sun, Ranfeng*; Liu, Yuxiu; Chen, Peiqi; Li, Yongqiang; Yang, Shaoxiang; Wang, Qingmin*. Synthesis and insecticidal activity studies of novel phenylpyrazole derivatives containing arylimine or carbimidate moiety. Bioorganic & Medicinal Chemistry, 2019, 27(21):115092.

9. Song, Xiangmin; Zhu, Xinyue; Li, Ting; Liang, Cai; Zhang, Meng; Shao, Yu; Tao, Jun; Sun, Ranfeng*. Dehydrozingerone Inspired Discovery of Potential Broad-Spectrum Fungicidal Agents as Ergosterol Biosynthesis Inhibitors. Journal of Agricultural and Food Chemistry, 2019, 67(41): 11354-11363.

10. Chen Peiqi; Song Xiangmin; Fan Yongmei; Kong Weihao, Zhang Hao, Sun Ranfeng*. Investigation of Novel Pesticides with Insecticidal and Antifungal Activities: Design, Synthesis and SAR Studies of Benzoylpyrimidinylurea Derivatives. Molecules, 2018, 23(9): 2203.

11. Song Xiangmin, Liu Chunjuan, Chen Peiqi, Zhang Hao, Sun Ranfeng*. Natural product-based pesticide discovery: design, synthesis and bioactivity studies of N-amino-maleimide derivatives. Molecules, 2018, 23(7): 1521.

12. Chen Peiqi, Liu Chunjuan, Hu Jianfeng, Zhang Hao, Sun Ranfeng*. Design, Synthesis and fungicidal activity studies of 3-ferrocenyl-N-acryloylmorpholine. Journal of Organometallic Chemistry, 2018, 854(1): 113-121.

13. Sun Ranfeng*, Liu Chunjuan, Zhang Hao, Wang Qingmin*. Benzoylurea chitin synthesis inhibitors. Journal of Agricultural and Food Chemistry, 2015, 63(31): 6847-6865.

14. Sun Ranfeng, Wang Huangdong, Hu Jianfeng, Zhao Jiudong, Zhang Hao*. Pyridine-phosphinimine ligand-accelerated Cu(I)-catalyzed azide-alkyne cycloaddition for preparation of 1-(pyridin-2-yl)-1,2,3-triazole derivatives. Organic & Biomolecular Chemistry, 2014, 12(31): 5954-5963.

15. Sun Ranfeng, Wang Ziwen, Li Yongqiang, Xiong Lixia, Liu Yuxiu, Wang Qingmin*. Design, synthesis, and insecticidal evaluation of new benzoylureas containing amide and sulfonate groups based on the sulfonylurea receptor protein binding site for diflubenzuron and glibenclamide. Journal of Agricultural and Food Chemistry, 2013, 61(3): 517-522.

16. Sun Ranfeng, Li Yongqiang, Xiong Lixia, Liu Yuxiu, Wang Qingmin*. Design, synthesis, and insecticidal evaluation of new benzoylureas containing isoxazoline and isoxazole group. Journal of Agricultural and Food Chemistry, 2011, 59(9): 4851-4859.

17. Sun Ranfeng, Liu Yuxiu, Zhang Yonglin, Xiong Lixia, Wang Qingmin*. Design and synthesis of benzoylphenylureas with fluorinated substituents on the aniline ring as insect growth regulators. Journal of Agricultural and Food Chemistry, 2011, 59(6): 2471-2477.

18. Sun Ranfeng, Li Yongqiang, Lü Maoyun, Xiong Lixia, Wang Qingmin*. Synthesis, larvicidal activity, and SAR studies of new benzoylphenylureas containing oxime ether and oxime ester group. Bioorganic & Medicinal Chemistry Letters, 2010, 20(15): 4693-4699.

19. Sun Ranfeng, Zhang Yonglin, Chen Li, Li Yongqiang, Li Qingshan, Song Haibin, Huang Runqiu, Bi Fuchun, Wang Qingmin*. Design, synthesis, and insecticidal activities of new N-benzoyl-N′-phenyl-N′-sulfenylureas. Journal of Agricultural and Food Chemistry, 2009, 57, 3661-3668.

20. Sun Ranfeng, Zhang Yonglin, Bi Fuchun, Wang Qingmin*. Design, synthesis, and bioactivity study of novel benzoylpyridazyl ureas. Journal of Agricultural and Food Chemistry, 2009, 57(9): 6356–6361.

21. Sun Ranfeng, Lü Maoyun, Chen Li, Li Qingshan, Song Haibin, Bi Fuchun, Huang Runqiu, Wang Qingmin*. Design, synthesis, bioactivity, and structure-activity relationship (SAR) studies of novel benzoylphenylureas containing oxime ether group. Journal of Agricultural and Food Chemistry, 2008, 56(23): 11376–11391.

獲獎及榮譽稱号：

1. 2022年，海南省“優秀研究生導師”

2. 2020年，榮獲“南海名家青年項目”

3. 2020年，榮獲“海南省領軍人才”

4. 2012年，“天津市優秀博士論文”獲得者；

5. 2012年，“全國優秀博士論文提名論文”獲得者；

6. 2010年，榮獲“南開大學優秀畢業研究生”稱号

團隊合影：