畜禽替抗飼料添加劑研發及抗病營養關鍵調控團隊-張海文

團隊名稱：畜禽替抗飼料添加劑研發及抗病營養關鍵調控技術示範團隊

所屬協同創新中心：南繁與熱帶高效農業協同創新中心

團隊負責人：

張海文，海南省E類人才，海南省科協青年托舉人才，海南省三區科技人才，省級科技特派員。主要研究方向為天然飼用抗生素替代品及功能性飼料添加劑。先後主持國家自然科學基金項目、海南省高層次人才項目、海南省科協青年創新人才項目等各級項目7項。出版專（編）著1部，參編書籍3部，發表學術論文60餘篇，部分研究成果發表在《International Journal of Biological Macromolecules》《Poultry Science》《Journal of Immunology》《Phytomedicine》《Journal of Agricultural and Food Chemistry》《Food & Function》《Molecular Pharmaceutics》《International Immunopharmacology》《Frontiers in Microbiology》《Animals》《Veterinary Immunology and Immunopathology》《Peptides》《Scientific Reports》等國際期刊。獲得365英国上市官网在线優秀班主任稱号，獲得三區科技人才基層服務工作年度考核優秀評價。

團隊研究方向：

1. 具有替代抗生素功能的畜禽飼料添加劑研發；

2. 通過營養手段調控畜禽腸道先天免疫功能；

3. 植物天然活性成分提取工藝研究與構效分析。

團隊成員：

1. 譚振，博士，講師；

2. 石惠宇，博士，講師。

團隊代表性成果：

1. 張海文, 管慶豐著,《動物營養與免疫概論》, 中國農業科學出版社, 2018, ISBN: 9787511635983.

2. Qin Xinyun^#; Nong Keyi^#; Liu Zhineng; Fang Xin; Zhang Bin; Chen Wanyan; Wang Zihan; Wu Yijia; Shi Huiyu; Wang Xuemei; Zhang Haiwen^*; Regulation of the intestinal flora using polysaccharides from Callicarpa nudiflora Hook to alleviate ulcerative colitis and the molecular mechanisms involved, International Journal of Biological Macromolecules, 2023, 258(Pt 1): 128887.（中科院1區，TOP期刊）

3. Fang Xin; Nong Keyi; Qin Xinyun; Liu Zhineng; Gao Feng; Jing Yuanli; Fan Haokai; Wang Zihan; Wang Xuemei; Zhang Haiwen^*; Effect of purple sweet potato-derived anthocyanins on heat stress response in Wenchang chickens and preliminary mechanism study, Poultry Science, 2023, 102(9): 102861. （中科院1區，TOP期刊）

4. Nong Keyi; Qin Xinyun; Liu Zhineng; Wang Zihan; Wu Yijia; Zhang Bin; Chen Wanyan; Fang Xin; Liu Youming; Wang Xuemei; Zhang Haiwen^*; Potential effects and mechanism of flavonoids extract of Callicarpa nudiflora Hook on DSS-induced colitis in mice, Phytomedicine, 2024, 128(3): 155523. （中科院1區，TOP期刊）

5. Liu Zhineng^#; Qin Xinyun^#; Nong Keyi; Fang Xin; Zhang Bin; Chen Wanyan; Wang Zihan; Wu Yijia; Shi Huiyu; Wang Xuemei; Zhang Haiwen^*; Oral administration of LfcinB alleviates DSS-induced colitis by improving the intestinal barrier and microbiota, Food & Function, 2024, 15(4): 2038 – 2051.（中科院1區，TOP期刊）

6. Nong Keyi^#; Liu Zhineng^#; Qin Xinyun; Chen Wanyan; Zhang Bin; Wu Yijia; Wang Zihan; Fang Xin; Liu Youming; Wang Xuemei; Sh Huiyui; Zhang Haiwen^*; Effect of the Pseudopleuronectes americanus-derived Pleurocidin on DSS-induced Ulcerative colitis in mice and its preliminary molecular mechanisms, International Immunopharmacology, 2024, 130: 111757. （中科院2區，TOP期刊）

7. Chen Tao; Hu Shihui; Zhang Haiwen^*; Guan Qingfeng; Yang Yuhui; Wang Xuemei^*; Anti-inflammatory effects of Dioscorea alata L. anthocyanins in a TNBS-induced colitis model, Food & Function, 2017, 8(2): 659-669.（中科院1區，TOP期刊）

8. Zhang Haiwen^*; Hua Rui; Zhang Bingxi; Guan Qingfeng; Zeng Jifeng; Wang Xuemei; Wang Beibei; Oral administration of bovine lactoferrin derived Lactoferricin (Lfcin) B could attenuate enterohemorrhagic Escherichia coli O157:H7 induced intestinal disease through improving intestinal barrier function and microbiota, Journal of Agricultural and Food Chemistry, 2019, 67(14): 3932-3945.（中科院1區，TOP期刊）

9. Qin Xinyun; Liu Zhineng; Nong Keyi; Fang Xin; Chen Wanyan; Zhang Bin; Wu Yijia; Wang Zihan; Shi Huiyu; Wang Xuemei; Zhang Haiwen^*; Porcine-derived antimicrobial peptide PR39 alleviates DSS-induced colitis via the NF-kappaB/MAPK pathway, International Immunopharmacology, 2024, 127: 111385. （中科院2區，TOP期刊）

10. Zhang Haiwen; Huang Liangmin; Hu Shihui; Qin Xinyun; Wang Xuemei^*; Moringa oleifera Leaf Powder as New Source of Protein-Based Feedstuff Improves Growth Performance and Cecal Microbial Diversity of Broiler Chicken, Animals (Basel), 2023, 13(6): 1104.

11. Nong Keyi^#; Liu Youming^#; Fang Xin; Qin Xinyun; Liu Zhineng; Zhang Haiwen^*; Effects of the Vitamin D3 on Alleviating the Oxidative Stress Induced by Diquat in Wenchang Chickens, Animals (Basel), 2023, 13(4): 711.

12. Fang Xin^#; Nong Keyi^#; Wang Zihan; Jing Yuanli; Gao Feng; Zeng Qiuyu; Wang Xuemei; Zhang Haiwen^*; Human cathelicidin LL-37 exerts amelioration effects against EHEC O157:H7 infection regarding inflammation, enteric dysbacteriosis, and impairment of gut barrier function, Peptides, 2023, 159: 170903.

13. Zhang Haiwen; Hua Rui; Zhang Bingxi; Guan Qingfeng; Wang Beibei^*; Zeng Jifeng; Wang Xuemei; Wu Kebang^*; Cathelicidin-derived PR-39 protects enterohemorrhagic Escherichia coli O157:H7 challenged mice by improving epithelial function and balancing the microbiota in the intestine, Scientific Reports, 2019, 9(1): 9456.

14. Zhang Haiwen^#; Xia Xi^#; Han Feifei; Jiang Qin; Rong Yili; Song Deguang; Wang Yizhen^*; Cathelicidin-BF, a novel antimicrobial peptide from Bungarus fasciatus, attenuates disease in a dextran sulfate sodium model of colitis, Molecular Pharmaceutics, 2015, 12(5): 1648-1661.

15. Zhang Haiwen^*; Liu Youming; Fang Xin; Gu Lihong; Luo Caiwei; Chen Lu; Wang qian; Vitamin D3 Protects Mice from Diquat-Induced Oxidative Stress through the NF-kappaB/Nrf2/HO-1 Signaling Pathway, Oxidative medicine and cellular longevity, 2021, 2021: 6776956.

16. Zhang Haiwen; Hua Rui; Zhang Bingxi; Zhang Xiaomeng; Yang Hui; Zhou Xihong ^*; Serine alleviates dextran sulfate sodium-induced colitis and regulates the gut microbiota in mice, Frontiers in microbiology, 2018, 9: 3062.

17. Zhang Haiwen; Zhang Bingxi; Zhang Xiaomeng; Wang Xuemei; Wu Kebang; Qingfeng Guan^*; Effects of cathelicidin-derived peptide from reptiles on lipopolysaccharide-induced intestinal inflammation in weaned piglets, Veterinary Immunology and Immunopathology, 2017, 192: 41-53.

18. Han Feifei^#; Zhang Haiwen^#; Xia Xi; Xiong Haitao; Song Deguang; Zong Xin; Wang Yizhen^*; Porcine beta defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitis, Journal of Immunology, 2015, 194(4): 1882-1893.

團隊合影：