張海文

男，博士，副教授，博士生導師，碩士生導師。

郵 箱：hwzhang@hainanu.edu.cn

365英国上市官网在线抗生素替代型飼料添加劑研發創新培育團隊 負責人；海南省科協青年托舉人才；海南省科技特派員；海南省地方雞産業體系核心成員。

研究領域

動物營養與免疫學、動物腸道營養調控、新型非常規飼料添加劑研發、植物提取物及其功能、畜禽健康高效養殖技術

教育背景

2010年9月-2015年6月 浙江大學動物科技學院 飼料科學研究所 博士（碩博連讀）

2006年9月-2010年6月 四川農業大學動物科技學院 動物科學專業 學士

工作經曆

2015年7月-2018年12月 365英国上市官网在线動物科技學院 講師

2019年1月-至今 365英国上市官网在线 副教授

講授課程

本科生課程：《實驗動物學》《專業英語》《畜牧業經濟管理》《動物毒理學》

研究生課程：《專業前沿讨論課程》《動物營養與飼料學》《生物信息學》

科研項目

1. 國家自然科學基金地區科學基金項目：豬源PR-39調控五指山豬腸道乳杆菌有機酸代謝保護腸黏膜屏障功能的分子機制，主持. 2023-01-01—2026-12-31.

2. 海南省重點研發項目：牛乳鐵蛋白肽和蛋清溶菌酶的肽酶融合高效表達系統構建及其應用，主持. 2025-02-19—2028-02-18.

3. 海南省自然科學基金高層次人才項目：海南産辣木葉源多糖(MOLP)通過調控腸道菌群代謝影響文昌雞體脂分配與沉積規律的機制研究，主持. 2025-03-01—2028-02-29.

4. 海南省高層次人才項目：海南紫大薯對熱應激下育肥期文昌雞脂質代謝的影響及作用機制，主持. 2020-12-26—2023-12-25

5. 海南省林業局項目：海南省農業遺傳資源調查，主持. 2020-01-01—2023-12-31

6. 海南省教育廳教改項目：以實驗動物學課程為介導搭建畜牧獸醫專業學生多元化知識架構，主持. 2020-01-01—2022-12-30

7. 海南省科協青年科技英才學術創新計劃項目：基于畜禽減抗的動物源抗菌肽篩選及其作用機理研究，主持. 2018-05-01—2020-12-31

8. 海南省自然科學基金項目：抗菌肽對斷奶仔豬腸道免疫的作用及調控機制，主持. 2016-01-01—2017-12-31

發表論文

1. Liu Z, Qin X, Zhang B, Nong K, Chen W, Yang Z, Lang W, Liu X, Li L, Wang X, Shi H, Zhang H. Proline rich-39 (PR-39) antimicrobial protein alleviated lipopolysaccharide-induced intestinal barrier dysfunction in piglets by altering intestinal flora associated bile acid metabolism and in turn regulating TGR-5/NF-κB/MLCK/MLC pathway. Int J Biol Macromol. 2025 Mar 10;307(Pt 1):141930. doi: 10.1016/j.ijbiomac.2025.141930. (中科院2區 TOP)

2. Lin M, Piao L, Zhao Z, Liao L, Wang D, Zhang H, Liu X. Therapeutic Potential of Cajanus cajan (L.) Millsp. Leaf Extract in Modulating Gut Microbiota and Immune Response for the Treatment of Inflammatory Bowel Disease. Pharmaceuticals (Basel). 2025 Jan 9;18(1):67. doi: 10.3390/ph18010067. PMID: 39861130; PMCID: PMC11769518.

3. Nong K, Qin X, Liu Z, Wang Z, Wu Y, Zhang B, Chen W, Fang X, Liu Y, Wang X, Zhang H. Potential effects and mechanism of flavonoids extract of Callicarpa nudiflora Hook on DSS-induced colitis in mice. Phytomedicine. 2024 Jun;128:155523. doi: 10.1016/j.phymed.2024.155523. (中科院1區 TOP).

4. Nong K, Liu Z, Qin X, Chen W, Zhang B, Wu Y, Wang Z, Fang X, Liu Y, Wang X, Shi H, Zhang H. Effect of the Pseudopleuronectes americanus-derived Pleurocidin on DSS-induced Ulcerative colitis in mice and its preliminary molecular mechanisms. Int Immunopharmacol. 2024 Mar 30;130:111757. doi: 10.1016/j.intimp.2024.111757. (中科院2區 TOP)

5. Liu Z, Nong K, Qin X, Fang X, Zhang B, Chen W, Wang Z, Wu Y, Shi H, Wang X, Liu Y, Guan Q, Zhang H. The antimicrobial peptide Abaecin alleviates colitis in mice by regulating inflammatory signaling pathways and intestinal microbial composition. Peptides. 2024 Mar;173:171154. doi: 10.1016/j.peptides.2024.171154.

6. Liu Z, Qin X, Nong K, Fang X, Zhang B, Chen W, Wang Z, Wu Y, Shi H, Wang X, Zhang H. Oral administration of LfcinB alleviates DSS-induced colitis by improving the intestinal barrier and microbiota. Food Funct. 2024 Feb 19;15(4):2038-2051. doi: 10.1039/d3fo05236b. (中科院1區 TOP)

7. Xinyun Qin, Keyi Nong, Zhineng Liu, Xin Fang, Bin Zhang, Wanyan Chen, Zihan Wang, Yijia Wu, Huiyu Shi, Xuemei Wang, Haiwen Zhang. Regulation of the intestinal flora using polysaccharides from Callicarpa nudiflora Hook to alleviate ulcerative colitis and the molecular mechanisms involved, Int J Biol Macromol, 2023 Dec 19;258(Pt 1):128887. doi: 10.1016/j.ijbiomac.2023.128887. (中科院1區 TOP)

8. Xin Fang, Keyi Nong, Xinyun Qin, Zhineng Liu, Feng Gao, Yuanli Jing, Haokai Fan, Zihan Wang, Xuemei Wang, Haiwen Zhang. Effect of purple sweet potato-derived anthocyanins on heat stress response in Wenchang chickens and preliminary mechanism study, Poultry Science, 2023 Sep;102(9):102861. doi: 10.1016/j.psj.2023.102861. (中科院1區 TOP)

9. Xinyun Qin, Zhineng Liu, Keyi Nong, Xin Fang, Wanyan Chen, Bin Zhang, Yijia Wu, Zihan Wang, Huiyu Shi, Xuemei Wang, Haiwen Zhang. Porcine-derived antimicrobial peptide PR39 alleviates DSS-induced colitis via the NF-κB/MAPK pathway, Int Immunopharmacol, 2023 Dec 18:127:111385. doi: 10.1016/j.intimp.2023.111385. (中科院2區 TOP)

10. Haiwen Zhang, Liangmin Huang, Shihui Hu, Xinyun Qin, Xuemei Wang. Moringa oleifera Leaf Powder as New Source of Protein-Based Feedstuff Improves Growth Performance and Cecal Microbial Diversity of Broiler Chicken, Animals, 2023 Mar 20;13(6):1104. doi: 10.3390/ani13061104. (中科院2區)

11. Keyi Nong 1, Youming Liu 1, Xin Fang 1, Xinyun Qin 1, Zhineng Liu 1, Haiwen Zhang. Effects of the Vitamin D3 on Alleviating the Oxidative Stress Induced by Diquat in Wenchang Chickens, Animals, 2023 Feb 17;13(4):711. doi: 10.3390/ani13040711. (中科院2區)

12. H. Zhang; Y. Liu;X. Fang;L. Gu;C. Luo;L. Chen and Q. Wang; Vitamin D3 Protects Mice from Diquat-Induced Oxidative Stress through the NF-kappaB/Nrf2/HO-1 Signaling Pathway, Oxidative medicine and cellular longevity, 2021, 2021: 6776956. (中科院2區)

13. Di, ZH; Zheng, JP; Zhang, HW; Wang, X; Guo, GY; Lin, YQ; Han, Q; Li, RS; Yang, N; Fan, LX; Zeng, JF. Natural outbreaks and molecular characteristics of Streptococcus agalactiae infection in farmed American bullfrog (Rana catesbeiana), Aquaculture, 2022, DOI 10.1016/j.aquaculture.2021.737885. (中科院1區 TOP)

14. Zhang Haiwen, Hua Rui, Zhang Bingxi, Guan Qingfeng, Zeng Jifeng, Wang Xuemei, Wang Beibei. Oral Administration of Bovine Lactoferrin-Derived Lactoferricin(Lfcin) B Could Attenuate Enterohemorrhagic Escherichia coli O157:H7 Induced Intestinal Disease through Improving Intestinal Barrier Function and Microbiota. J. Agric. Food Chem.DOI: 10.1021/acs.jafc.9b00861. (中科院1區 TOP)

15. Haiwen Zhang, Bingxi Zhang, Xiaomeng Zhang, Xuemei Wang, Kebang Wu, Qingfeng Guan. Effects of cathelicidin-derived peptide from reptiles on lipopolysaccharide-induced intestinal inflammation in weaned piglets. Vet Immunol Immunopathol. 2017, Oct; 192:41-53. doi: 10.1016/j. (中科院3區)

16. Zhang haiwen, Hua rui, Zhang bingxi, Guan qingfeng, Wang Beibei, Zeng jifeng, Wang xuemei, Wu kebang. Cathelicidin-derived PR39 protects enterohemorrhagic Escherichia coli O157:H7 challenged mice by improving epithelial function and balancing the microbiota in the intestine. Sci Rep. 2019 Jul 1;9(1):9456. (中科院3區)

17. Zhang haiwen, Hua rui, Zhang bingxi, Zhang xiaomeng, Yang hui, Zhou xihong. Serine Alleviates Dextran Sulfate Sodium-Induced Colitis and Regulates the Gut Microbiota in Mice. Front Microbiol. 2018 Dec 10;9:3062. (中科院2區 TOP)

18. Haiwen, Zhang, Xi Xia, Feifei Han, Qin Jiang, Yili Rong, Deguang Song, and Yizhen Wang. Cathelicidin-BF, a novel antimicrobial peptide from Bungarus fasciatus, attenuates disease in a dextran sulfate sodium model of colitis. Mol Pharm. 2015, 12 (5): 1648–1661. (中科院2區)

19. Feifei Han, Haiwen Zhang (co-first author), Xi Xia, Haitao Xiong, Deguang Song, Xin Zong, and Yizhen Wang. Porcine beta-defensin 2 attenuates inflammation and mucosal lesions in dextran sodium sulfate-induced colitis. J Immunol. 2015, 194(4): p. 1882-93. (中科院2區 TOP)

20. Tao Chen, Shihui Hu, Haiwen Zhang*（co-corresponding author）, Qingfeng Guan, Yuhui Yang, Xuemei Wang*. 2017. Anti-inflammatory effects of Dioscorea alata L.anthocyanins in a TNBS-induced colitis model. Food & Function. DOI: 10.1039/c6fo01273f. (中科院1區 TOP)

21. Chao Luan, Haiwen Zhang, Deguang Song, Yonggang Xie, Jie Feng, and Yizhen Wang. Expressing antimicrobial peptide cathelicidin-BF in Bacillus subtilis using SUMO technology. Appl Microbiol Biotechnol. 2014, 98(8):p.3651-58.

22. Deguang Song, Xin Zong, Haiwen Zhang, Tenghao Wang, Hongbo Yi, Chao Luan, and Y. Wang. Antimicrobial peptide Cathelicidin-BF prevents intestinal barrier dysfunction in a mouse model of endotoxemia. Int Immunopharmacol. 2015, 25(1): p. 141-7.

23. Hongbo Yi, Caihua Yu, Haiwen Zhang, Denghu Jiang, Yizhen Wang. Cathelicidin-BF suppresses intestinal inflammation by inhibiting the nuclear factor-κB signaling pathway and enhancing the phagocytosis of immune cells via STAT-1 in weanling piglets. Int Immunopharmacol. 2015, 28 (1) : p. 61–69.

24. Yonggang Xie, Chao Luan, Haiwen Zhang, Feifei Han, Jie Feng, Y.J. Choi, D. Groleau, and Yizhen Wang. Effects of thioredoxin: SUMO and intein on soluble fusion expression of an antimicrobial peptide OG2 in Escherichia coli. Protein Pept Lett. 2013, 20(1): p. 54-60. IF=1.994

25. Yonggang Xie, Feifei Han, Chao Luan, Haiwen Zhang, Jie Feng, Choi YJ, Groleau D, Yizhen Wang. High-Yield Soluble Expression and Simple Purification of the Antimicrobial Peptide OG2 Using the Intein System in Escherichia coli. BioMed Research International. 2013: 754319.

26. Chao Luan, Yonggang Xie, Yutian Pu , Haiwen Zhang, Feifei Han, Jie Feng, and Yizhen Wang. Recombinant expression of antimicrobial peptides using a novel self-cleaving aggregation tag in Escherichia coli. Can J Microbiol. 2014, 60(3): p. 113-20.

27. Yili Rong, Zeqing Lu, Haiwen Zhang, Yizhen Wang*. Effects of Casein glycomacropeptide supplementation on Escherichia coli K88 challenged piglets. Animal nutrition. 2015.

28. Xinxia Wang, Yizhen Wang, Yongjin Li, Ming Huang, Yang Gao, Xianfeng Xue, Haiwen Zhang. Responses of yellow catfish (Pelteobagrus fulvidraco) to different dietary concentrations of aflatoxin B1 (AFB1) and evaluation of an aflatoxin binder in offsetting its negative effects. Ciencias Marinas. 2016.

29. Qin Jiang, Haiwen Zhang, Yonggang Xie, Yizhen Wang. Recombinant expression of porcine lactoferrin peptide LF-6 with intein technology and its immunomodulatory function in ETEC K88-infected mice. Int Immunopharmacol. 2016, 39(1): p. 181-191.

30. Feifei Han, Zeqing Lu, Yifan Liu, Xi Xia, Haiwen Zhang, Yizhen Wang. Cathelicidin-BF ameliorates lipopolysaccharide-induced intestinal epithelial barrier disruption in rat. Life Science. 2016, 152(1): p. 199-209.

另以第一或通訊作者發表中文核心期刊論文30篇（略）。

出版著作

1.《動物營養與免疫學概論》，中國農業科學技術出版社，10萬字；

2.《生物技術與工程原理及應用》，中國原子能出版社，7萬字。

另作為主要成員參與編寫書籍2部。