王鳳陽

男，博士，教授，博導。

國家肉羊産業技術體系疾病防控研究室主任, 崗位科學家。

海南省熱帶動物繁育與疫病研究重點實驗室主任。

郵箱：990805@hainanu.edu.cn;fywang68@163.com

通訊地址：海南省海口市人民大道58号 郵政編碼570228

研究領域

獸醫傳染病學、免疫學

碩士招生專業

畜牧學碩、獸醫專碩

博士招生專業

生物化學與分子生物學

教育背景

1998年-2001年 軍事醫學科學院11所（原軍需大學研究所），博士。師從殷震院士。

工作經曆

2001年-2003年 清華大學生物系博士後

2003年-2004年 華盛頓大學（聖路易斯）醫學院Research Associate

2004年-至今365英国上市官网在线教授

講授課程

《獸醫傳染病學》（本科）

科研項目

1. 國家肉羊産業技術體系崗位科學家，國家級。

2.國家重點研發計劃項目, 國家級，課題（2018YFD0501904）主持。

3.其它項目3項。

發表論文

1. He M, Li H, Zhang Z, Jiang J, Li H, Yang W, Cheng Y, Gao H, Chen Q, Du L, Chen S*, Man C, Wang F* （2022） Microbiological characteristics and pathogenesis of Klebsiella pneumoniae isolated from Hainan black goat. Vet. Sci. 9, 471

2. Li L, Li K, Bian Z, Chen Z, Li B, Cu K, Wang F*(2022) Association between body weight and distal gut microbes in Hainan black goats at weaning age. Front. Microbiol., DOI 10.3389/fmicb.2022.951473.

3. Chen Q, Chai Y, Zhang W, Cheng Y, Zhang Z, An Q, Chen S, Man C, Du L, Zhang W*, Wang F*(2022) Whole-genome sequencing reveals the genomic characteristics and selection signatures of Hainan black goat. Genes. 13(9):1539.

4. Zhang X, Cui K, Wen X, Li L, Yu X, Li B, Lin H, He H*, Wang F*(2022) The association between gut microbiome diversity and composition and heat tolerance in cattle. Microorganisms. 10(8):1672.

5. Chen S, Wang C, Chen Q, Zhao D, Liu Y, Zhao S, Fu S, He X, Yang B, Zhao Q, An Q, Zhang Z, Cheng Y, Man C, Liu G, Wei X, Zhang W*, Du L*, Wang F*(2022) Downregulation of three novel miRNAs in the lymph nodes of sheep immunized with the Brucella suis Strain 2 vaccine. Front Vet Sci. DOI: 10.3389/fvets.2022.813170.

6.Chen Q, Zhang Z, Chen S, Chen J, Cheng Y, Liu A, Li B, Chen Z, Zheng Y, Man C, Du L, Wang F* (2021) Genome-wide differential expression profiling of pulmonary circRNAs associated with immune reaction to Pasteurella multocida in goats.Front Vet Sci.DOI:10.3389/fvets. 2021.615405

7. Jiao H*, Zhao Y, Zhou Z, Li W, Li B, Gu G, Luo Y, Shuai X, Fan C, Wu L, Chen J, Huang Q, Wang F*, Liu J*(2021) Identifying circular RNAs in HepG2 expressing Genotype IV Swine Hepatitis E Virus ORF3 via whole genome sequencing. Cell Transplant.DOI: 10.1177/09636897211055042.

8. Li B, Chen S, Wang C, Chen Q, Man C, An Q, Zhang Z, Liu Z, Du L*, Wang F* (2021) Integrated mRNA-seq and miRNA-seq analysis of goat fibroblasts response to Brucella Melitensis strain M5-90. PeerJ.DOI:10.7717/peerj.11679.

9. Pang F, Wang X, Chen Z, Zhang Z, Zhang M, Wang C, Yang X, An Q, Du L, Wang F* (2020) Integrated analysis of differentially expressed miRNAs and mRNAs in goat skin fibroblast cells in response to Orf virus infection reveals that cfa-let-7a regulates thrombospondin 1 expression. Viruses.DOI:10.3390/v12010118.

10.JiaoH, Nie X, Zhu H, Li B, Pang F, Yang X, Cao R, Yang X, Zhu S, Peng D, Li Y, Li G, Zhang Z, Huang H, Xu K, Zhao T, Cheng Y, Chen C*, Du L*, Wang F* (2020) miR-146b-5pplays acriticalrole in theregulation ofautophagy in ∆per Brucella melitensis-infected RAW264.7cells.Biomed Res Int. 2020:1953242.

11.Pang F, Chen Z, Wang C, Zhang M, Zhang Z, Yang X, Zheng Y, Liu A, Cheng Y, Chen J, Li B, Du L, Wang F* (2019) Comprehensive analysis of differentially expressed microRNAs and mRNAs in MDBK cells expressing bovine papillomavirus E5 oncogene. PeerJ. 2019.DOI:10.7717/peerj.8098.

12. Pang F, Zhang M, Li G, Zhang Z, Huang H, Li B, Wang C, Yang X, Zheng Y, An Q, Zhang L, Du L, Wang F* (2019) Integrated mRNA and miRNA profiling in NIH/3T3 cells in response to bovine papillomavirus E6 gene expression. PeerJ. 2019.DOI:10.7717/peerj.7442.

13. Pang F, Zhang M, Yang X, Li G, Zhu S, Nie X, Cao R, Yang X, Zhang Z, Huang H, Li B, Wang C, Du L, Wang F* (2019) Genome-wide analysis of circular RNAs in goat skin fibroblast cells in response to Orf virus infection. Peer J. 2019.DOI:10.7717/peerj.6267.

14.Zhu H, Jiao H, Nie X, Li B, Xu K, Pang F, Cao R, Zhu S, Yang X, Zhang Z, Peng D, Li Y, Li G, Huang H, Chen C*, Du L*, Wang F* (2018) Alterations of microRNAs and their predicted targeting mRNAs expression in RAW264.7 macrophages infected with Omp25 mutant Brucella melitensis. Innate Immun. 2018.DOI:10.1177/1753425918792298.

15.Peng D, Pang F, Cao R, Zhu S, Yang X, Nie X, Zhang Z, Li B, Huang H, Li Y, Li G, Du L, Wang F* (2018) Upregulation of Immune Process-Associated Genes in RAW264.7 Macrophage Cells in Response to Burkholderia pseudomallei Infection Biomed Res Int. 2018.DOI:10.1155/2018/1235097.

16. Rong H, Jiao H, Hao Y, Pang F, Li G, Peng D, Li Y, Wang Y, Zhang H, Fan Q, Wang F*, Chen C*, Du L* (2017) CD14 gene silencing alters the microRNA expression profile of RAW264.7 cells stimulated by Brucella melitensis infection. Innate Immun. 2017:1753425917707025.DOI:10.1177/1753425917707025.

17. Xu K, Guo S, Zhao T, Zhu H, Jiao H, Shi Q, Pang F, Li Y, Li G, Peng D, Nie X, Cheng Y, Wu K, Du L, Cui K, Zhang W*, Wang F* (2016) Transcriptome analysis of HepG2 cells expressing ORF3 from Swine Hepatitis E Virus to determine the effects of ORF3 on host cells. Biomed Res Int. 2016:1648030.DOI:10.1155/2016/1648030.

18. Jiao H, Jia X, Zhao T, Rong H, Zhang J, Cheng Y, Zhu H, Xu K, Guo S, Shi Q, Zhang H, Wang F*, Chen C*, Du L* (2016) Upregulation of TDAG51 is a dependent factor of LPS induced RAW264.7 macrophages proliferation and cell cycle progression. Immunopharmacol Immunotoxicol. 38: 124-130.

19. Chen H, Jiao H, Cheng Y, Xu K, Jia X, Shi Q, Guo S, Wang M, Du L, Wang F* (2016) In vitro and in vivo immunomodulatory activity of Okra (Abelmoschus esculentus L.) polysaccharides. J Med Food.19 (3)：253–265.

20. Cheng Y, Du L, Jiao H, Zhu H, Xu K, Guo S, Shi Q, Zhao T, Pang F, Jia X, Wang F* (2015) Mmu-miR-27a-5p-Dependent Upregulation of MCPIP1 Inhibits the Inflammatory Response in LPS-Induced RAW264.7 Macrophage Cells. Biomed Res Int. 2015: 607692.DOI:10.1155/2015/607692.

21. Pang F, Shi Q, Du L, Zhao T, Cheng Y, Jiao H, Zhao J, Wang M, Rong H, Zhou H, Wang F* (2014) Complete genome sequence of Bovine Papillomavirus genotype 13 from local yellow cattle in Hainan Province, China. Genome Announc, 4; 2(6).

22. Du L, Rong H, Cheng Y, Guo S, Shi Q, Jia X, Zhu H, Hao Y, Xu K, Zhang J, Jiao H, Zhao T, Zhang H, Chen C and Wang F* (2014) Identification of microRNAs dysregulated in CD14 gene silencing RAW264.7 macrophage cells. Inflammation. 37(1): 287-294.

23. Cheng Y, Du L, Shi Q, Jiao H, Zhang X, Hao Y, Rong H, Zhang J, Jia X, Guo S, Kuang W, Zhang H, Chen C, Wang F* (2013) Identification of miR-221 and 222 as important regulators in genotype IV swine hepatitis E virus ORF3expressing HEK 293 cells. Virus Genes. 47(1): 49-55.

24. Jiao H, Du L, Hao Y, Cheng Y, Luo J, Kuang W, Zhang D, Lei M, Jia X, Zhang X, Qi C, He H*, Wang F* (2013) Effective inhibition of mRNA accumulation and protein expression of H5N1 avian influenza virus NS1 gene in vitro by small interfering RNAs. Folia Microbiol (Praha). 58(4): 335-342.

25. Cheng Y, Kuang W, Hao Y, Zhang D, Lei M, Du L, Jiao H, Zhang X, Wang F* (2012) Downregulation of miR-27a* and miR-532-5p and upregulation of miR-146a and miR-155 in LPS-induced RAW264.7 macrophage cells. Inflammation. 2012 Aug;35(4):1308-13.

26. Lei M, Du L, Jiao H, Cheng Y, Zhang D, Hao Y, Li G, Qiu W, Fan Q, Li C, Chen C*, Wang F* (2012) Inhibition of mCD14 inhibits TNFα secretion and NO production in RAW264.7 cells stimulated by Brucella melitensis infection. Vet Microbiol. 160(3-4):362-368.

27. Lei M, Jiao H, Liu T, Du L, Cheng Y, Zhang D, Hao Y, Man C, Wang F* (2011) siRNA targeting mCD14 inhibits TNF-α, MIP-2, and IL-6 secretion and NO production from LPS-induced RAW264.7 cells. Appl Microbiol Biotechnol. 92(1):115-124.

28. Liu T, Lei M, Jiao H, Du L, Cheng Y, Zhang D, Hao Y, Man C, Wang F* (2011) RNA interference induces effective inhibition of mRNA accumulation and protein expression of SHEV ORF3 gene in vitro. Curr Microbiol. 62(5):1355-1362.

出版著作

1. 《獸醫微生物學》，科學出版社，2007. 主譯.

2. 《細菌分子遺傳學》，科學出版社，2013. 主譯.

3. 《畜牧微生物學》（第五版），中國農業出版社，2009. 參編.

4. 《畜牧微生物學》（第六版），中國農業出版社，2017. 參編.

5. 《綿羊與山羊醫學》（第二版），中國農業大學出版社. 2020. 主譯.

獎勵

1. 2015年海南省科學技術進步獎一等獎（排名第一）；

2. 2013年海南省科學技術進步獎一等獎（排名第一）；

3. 2011年海南省科學技術進步獎三等獎（排名第一）；

4. 2008年海南省科技成果轉化獎一等獎（排名第一）；

5. 海南省高校優秀科研成果獎4項（均排名第一）；

6. 365英国上市官网在线“吳多泰博士科研成果獎”4項（均排名第一）。

榮譽

1. 2019年，海南省傑出人才；

2. 2017年，國家百千萬人才工程；

3. 2017年，國家有突出貢獻的中青年專家；

4. 2016年，國務院政府特殊津貼專家；

5. 2015年，海南省“515”人才工程第一層次；

6. 2014年，海南省有突出貢獻的優秀專家。